PathMap Literature Based Discovery Engine

Share your Discovery:

Guaranteed to find unpublished literature based discoveries.

Clear Search

Experiment #00000069

Keyword Analysis: diabetes; retinal diabetic neuropathy; ganglion cells; synapses; SPG302; tazbentetol; visual function; synaptic regeneration; neuroprotection; blindness; glaucoma

Glucose _gates_from_glucose Mitochondria _gates_to_mitochondria Mitochondrial Dysfunction _gates_from_mitochondrial_dysfunction Retinal Ganglion Cells _gates_to_retinal_ganglion_cells SPG302 Treatment _gates_from_spg302_treatment
View Results
Experiment #00000023

Does misfolded TDP43 affect Retinal Ganglion Cell STMN2 ability to repair in a similar way as what how it was shown to affect motor neurons with cryptic mis-splicing?

TDP-43 pathology _gates_from_tdp_43_pathology RNA Splicing _gates_to_rna_splicing _gates_from_rna_splicing Stathmin 2 _gates_to_stathmin_2 Vitreous Body _gates_to_vitreous_body DNA-Binding Protein-43
View Results
Experiment #00000016

Analyze the potential for zinc-binding competition between synaptic transporters (e.g., SLC39A8, ZnT3) and ALS-associated proteins (RGNEF, TDP-43) in the RGC-thalamic axis. Can this competition explain the coexistence of RGC excitotoxicity and STMN2 depletion in clinical samples?

TAR DNA-Binding Protein 43 _gates_from_tar_dna_binding_protein_43 Stathmin 2 _gates_to_stathmin_2 SLC39A8 protein, human _gates_from_slc39a8_protein__human Zinc _gates_to_zinc Excitotoxicity _gates_from_excitotoxicity
View Results
Experiment #00000013

Can BMAA, a known glutamate mimic, cause hyperexcited retinal ganglion cells and cause them to "misfire" corollary discharge?

Amino Acids, Diamino _gates_from_amino_acids__diamino Retina _gates_to_retina _gates_from_retina Corollary Discharge _gates_to_corollary_discharge NMDA receptors _gates_to_nmda_receptors NMDA receptor activation
View Results